Best of ASCO 2025 narrative review article – Skin cancer
DREAMseq: A phase III trial of treatment sequences in BRAFV600-mutant (m) metastatic melanoma (MM) – Final clinical results BRAF is one of the most commonly mutated oncogenes in melanoma1. Patients with BRAF-mutant MM can be treated either with targeted therapy (TT) or with combined immunotherapy (IO)2–4 such as nivolumab and ipilimumab5 both of which have […]
Best of ASCO 2025 – Survivorship
Introduction For the section Survivorship and Symptom Control at the Sociedade Portuguesa de Oncologia (SPO) Best of ASCO 2025 – Official Licensed Annual Meeting, we aimed to select abstracts answering tangible questions regarding the management of frequent challenges encountered by oncologists on their daily routine. Evidence has shown that the development of optimized supportive care […]
Testing positive after genetic testing for hereditary cancer: what’s next?
Introduction The growing integration of genetics into clinical oncology practice has led to an increase in the number of individuals (both cancer survivors and those without prior oncological diagnoses) identified with genetic variants associated with hereditary cancer. These individuals require a multidisciplinary approach to manage their cancer risk, and various structures have been established across […]
The role of Epstein-Barr virus in nasopharyngeal carcinoma: a case report
Introduction Nasopharyngeal carcinoma (NPC) is classified into three subtypes: keratinizing squamous cell carcinoma (type 1), non-keratinizing squamous cell carcinoma (type 2), and undifferentiated carcinoma (type 3)1,2. The initial symptoms of NPC may be subtle, with an estimated delay of approximately 6 weeks between symptom onset and the first medical evaluation1. Approximately 70% of patients present […]
Editorial
Dear readers, Last September, the Head and Neck Cancer Study Group (Grupo de Estudos de Cancro da Cabeça e Pescoço – GECCP) organized its 14th National Symposium. Some of the original presentations were converted into five of the articles featured in this issue. The interim analysis of a prospective multicenter Portuguese study, aiming to determine […]
Tumor Ki67 after a 2-week aromatase inhibitor run-in in patients with ER+ early breast cancer proposed for up-front surgery
Introduction Breast cancer (BC) is the most frequently diagnosed cancer and the first cause of cancer-related death in women1. Most are diagnosed at an early stage, with about 5-15% of patients presenting with metastatic disease up-front2. BC is a heterogeneous group of tumors with different histological, prognostic, and clinical aspects3. Endocrine-receptor positive (ER+) tumors represent […]
Cancro em comorbilidade com doença mental grave: desigualdades nos cuidados de saúde e prognóstico
Introdução A doença mental grave (DMG) representa uma condição psiquiátrica com impacto substancial na vida quotidiana de um indivíduo, interferindo significativamente no seu funcionamento global1,2. Este termo engloba um espectro de perturbações mentais, comportamentais e emocionais, incluindo esquizofrenia e outras perturbações psicóticas, perturbação bipolar e depressão major1. Em meados do século XX, Emil Kraepelin observou […]
Diagnóstico incidental de carcinoma do quisto do canal tireoglosso: o que fazer a seguir?
Introdução O quisto do canal tireoglosso é um quisto congénito comum do pescoço, constituindo cerca de 7% das massas cervicais anteriores em adultos1. Pode ocorrer em qualquer ponto ao longo da migração embrionária da tiroide. Geralmente, o canal tireoglosso atrofia e desaparece entre a 7a e a 10a semana de desenvolvimento embrionário. Quando não ocorre […]
Carcinoma epidermóide da orofaringe, a propósito de um caso clínico
Introdução O cancro da cavidade oral constitui uma das neoplasias mais frequentes a nível mundial. São maioritariamente caracterizados com histologia de carcinoma epidermoide e apresentam habitualmente um prognóstico reservado em estádios mais avançados, com taxas de mortalidade bastante elevadas. Têm como principais fatores de risco o consumo de tabaco, álcool e estão associados a infeção […]
Sentinel lymph node biopsy’s role in oral cavity cancer: analysis of cases and literature review
Introduction Oral cavity squamous cell carcinoma (OCSCC) is the most common histological type of oral cavity cancer. While early-stage (cT1-2) OCSCC often presents without clinically detectable cervical lymph node metastasis (cN0), between 20% and 30% of these patients have the risk of concealing occult metastasis1. The presence of lymph node metastasis is the most important […]