Hyperbaric oxygen therapy for radiation-induced cystitis: a prospective study using the portuguese navy radiation-induced cystitis scale
Introduction Radiotherapy (RT) is a cornerstone of multidisciplinary cancer treatment and is administered to a substantial proportion of oncology patients worldwide. Despite progressive refinements in RT planning and delivery, late radiation-induced tissue injuries (LRTIs) may still emerge after a symptom-free latency period ranging from a few months to several decades. The true incidence of LRTIs […]
Ovarian cancer in Portugal: a real-world evidence review
Key issues • Real-world evidence (RWE) refers to the analysis and interpretation of data from real-world practice. • RWE may help clinicians and health policymakers identify gaps in ovarian cancer (OC) patient pathways and define strategies to overcome the difficulties. • RWE on BRCA mutations in Portuguese OC patients aligns with the published data. • […]
Current perspectives on endometrial cancer in Portugal: prevention, diagnosis, clinical management, challenges and opportunities
Introduction Endometrial cancer (EC) was the second most common gynecological cancer in Portugal, with an age-standardized incidence of 8.9/100.000 and a mortality of 3 deaths/100.000 in 2022.1,2 The global increase in EC of over 130% in three decades is mirrored at the national level and is primarily driven by aging, obesity, and metabolic disorders.3–6 EC […]
Olaparib desensitization using the non-crushable tablet formulation
Introduction Drug allergy accounts for 10-15% of adverse drug reactions.1 Type I, immunoglobulin E (IgE)-mediated reactions occur within minutes to hours after exposure.1 Adverse drug reactions are reported in approximately 5% of oncology treatments.2 Based on presentation, severity, and mediators released, these reactions can be classified according to phenotype and endotype, reflecting the underlying immune […]
Breast carcinoma with neuroendocrine differentiation: a personalized therapeutic approach using somatostatin analogs
Introduction Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related mortality among women worldwide.1 Breast carcinomas with neuroendocrine differentiation represent a rare entity, accounting for < 1% of all breast neoplasms.2,3 According to the most recent World Health Organization (WHO) classification, these neoplasms are currently included within the group of […]
Case report: fallopian tube metastasis to the breast
Introduction Ovarian, fallopian tube, and peritoneal (OTP) cancer is the second most common gynecological malignancy in developed countries, with an estimated prevalence in Portugal in 2020 of 9.5/100,000 women.1 Despite its relatively low incidence, OTP carcinoma is among the most lethal cancers in women, exhibiting high mortality rates.2 The most frequent histological subtype is high-grade […]
Hepatic adrenal rest tumor: a pitfall in liver lesions
A 71-year-old male was referred to our hospital for hepatology assessment due to suspected chronic liver disease. His past medical history was unremarkable, except for moderate chronic alcohol consumption. Physical examination and vital signs were within normal limits. Laboratory evaluation revealed normal alpha-fetoprotein levels, normal liver function tests, and normal prothrombin time. Considering the patient’s […]
Right paratracheal pseudotumor: an interesting radiological appearance
Pulmonary pseudotumors are relatively common radiologic findings. Most frequently caused by a loculated pleural effusion confined to the pleural fissures, other etiologies have been described, such as inflammation, atelectasis, fat, mucoid, or calcifying impaction, among others.1 We report the case of a 62-year-old man, previously a house-constructor, current smoker (45 pack-years), with a known history […]